Homologous Blood Syndrome

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Protected with Nucleated Elements of Homologous Blood

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Homologous recombination resolution defect in werner syndrome.

Werner syndrome (WRN) is an uncommon autosomal recessive disease whose phenotype includes features of premature aging, genetic instability, and an elevated risk of cancer. We used three different experimental strategies to show that WRN cellular phenotypes of limited cell division potential, DNA damage hypersensitivity, and defective homologous recombination (HR) are interrelated. WRN cell surv...

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Reduction in Homologous Blood Transfusions Using a Low Prime Circuit

Due to a low estimated blood volume, small adults (weight less than 70 kg) undergoing cardiopulmonary bypass (CPB) are at highest risk for low hematocrit and homologous blood transfusion (HBT). To determine whether reductions in HBT could be achieved we compared the use of a low prime circuit (1400 ml) with our standard (2200 ml) cardiopulmonary bypass (CPB) circuit. Eighty consecutive adult pa...

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The Bloom's syndrome gene product is homologous to RecQ helicases

The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A candidate for BLM was identified by direct selection of a cDNA derived from a 250 kb segment of the genome to which BLM had been assigned by somatic crossover point mapping. In this novel mapping method, cells were used from persons with BS that had undergone intragenic recom...

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Detection of homologous blood transfusion by flow cytometry: a deterrent against blood doping.

Blood doping has the explicit goal of increasing the level of circulating hemoglobin in the bloodstream to enable greater oxygen transport during exercise and therefore to improve endurance performance. Tests have been developed that are capable of detecting athletes using either recombinant human erythropoietins or hemoglobin-based oxygen carriers to boost hemoglobin levels, but to date there ...

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ژورنال

عنوان ژورنال: Annals of Surgery

سال: 1962

ISSN: 0003-4932

DOI: 10.1097/00000658-196211000-00013